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The MIRD committee, comprising experts from various fields, including nuclear medicine, radiation oncology, and physics, developed these guidelines to standardize the administration of I-131 therapy. By providing a framework for calculating radiation doses, MIRD237 aims to ensure that patients receive optimal treatment while minimizing the risks associated with radiation exposure.

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To validate their findings, the researchers turned to breast cancer biology. They worked with MCF-7 and MDA-MB-231 breast cancer cell lines, which are known to harbor lower levels of hsa-miR-125b compared to normal cells. The results were remarkable:

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